Vimpat generic Lacosamide: Uses, Side Effects

Vimpat generic, Lacosamide Uses, Lacosamide Side Effects, Lacosamide Dose, Lacosamide Dosage forms, Lacosamide drug Interactions, Lacosamide food Interactions, Lacosamide Mechanism of Action, Lacosamide price

Vimpat generic drug Lacosamide

Lacosamide is used in Epilepsy. it is available under the brand names Vimpat, Motpoly XR and also available in generic drugs.

Common Brands : Vimpat, Motpoly XR

Lacosamide generic names:

Availability: Prescription only

Drug Class: Anticonvulsants (Antiepileptic)

Controlled Substance Classification: Schedule V

Vimpat generic drug Lacosamide : Uses

• Used for Epilepsy, primary generalized tonic-clonic (PGTC) seizures, partial-onset seizures
• Drug Class: Anticonvulsants

Vimpat generic drug Lacosamide : Side Effects

Common side effects of Lacosamide include:

• headache, 
• dizziness, 
• drowsiness, 
• double vision, and 
• nausea

Serious side effects of Lacosamide include:

• hives, 
• difficulty breathing, 
• swelling of the face, lips, tongue, or throat, 
• skin rash, 
• fever, 
• swollen glands, 
• muscle aches, 
• severe weakness, 
• unusual bruising, 
• yellowing of the skin or eyes (jaundice), 
• mood or behavior changes, 
• depression, 
• anxiety, 
• panic attacks, 
• trouble sleeping, 
• impulsive behavior, 
• irritableness, 
• agitation, 
• hostility, 
• aggression, 
• restlessness, 
• hyperactivity (mental or physical), 
• thoughts of self-harm, 
• lightheadedness, 
• severe dizziness, 
• problems with balance or muscle movement, 
• chest pain, 
• shortness of breath, 
• fast or pounding heartbeats, 
• very slow heartbeats, and
• dark urine

This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions.

Vimpat generic drug Lacosamide : Dose and Dosage forms

Adult and pediatric dosage

Tablet: Schedule V

• 50mg
• 100mg
• 150mg
• 200mg

Injectable solution: Schedule V

• 200mg/20mL

Oral solution: Schedule V

• 10mg/mL

Partial Onset Seizures

• Adult dosage
• Monotherapy
  • 100 mg orally/IV every 12 hours initially, then increase dose at weekly intervals by 50 mg Orally/IV twice daily up to recommended dose of 150-200 mg twice daily (300-400 mg/day) or
  • 200 mg orally/IV as a single loading dose, followed 12 hours later by 100 mg orally/IV twice daily; then increase dose at weekly intervals by 50 mg twice daily; up to a recommended dose of 150-200 mg twice daily (300-400 mg/day)
• Adjunct therapy
  • Initial: 50 mg orally/IV every 12 hours
  • Based on response and tolerability, increase dose at weekly intervals by 50 mg orally/IV twice daily; up to a recommended dose of 100-200 mg twice daily (200-400 mg/day)
• Pediatric dosage
  • Children younger than 1 month of age: Safety and efficacy not established
  • Children 1 month to 17 years: 
  • Weighing less than 6 kg:
    • IV: 0.66 mg/kg thrice daily, then, based on response and tolerability, increase dose at weekly intervals by 0.66 mg/kg three times daily; up to recommended 2.5-5 mg/kg thrice daily (7.5-15 mg/kg/day)
    • Orally: 1 mg/kg twice daily (2 mg/kg/day), then, based on response and tolerability, increase dose at weekly intervals by 1 mg/kg twice daily (2 mg/kg/day), up to 3.75-7.5 mg/kg twice daily (7.5-15 mg/kg/day)
  • Weighing 6 kg but less than 30 kg: 1 mg/kg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 1 mg/kg orally/IV twice daily, up to recommended 3-6 mg/kg orally/IV twice daily (6-12 mg/kg/day)
    • Weighing 30 kg but less than 50 kg: 1 mg/kg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 1 mg/kg orally/IV twice daily, up to recommended 2-4 mg/kg orally twice daily (4-8 mg/kg/day)
    • Weighing 50 kg or over: 50 mg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 50 mg orally/IV twice daily, up to recommended 150-200 mg orally/IV twice daily (300-400 mg/day) for monotherapy or 100-200 mg orally/IV twice daily (200-400 mg/day) for adjunctive therapy
• Primary Generalized Tonic-Clonic Seizures
• Adult dosage
  • Initial: 50 mg orally/IV every 12 hours
  • Based on response and tolerability, increase dose at weekly intervals by 50 mg orally/IV twice daily; up to a recommended dose of 100-200 mg twice daily (200-400 mg/day).
• Pediatric dosage
  • Children younger than 4 years of age: Safety and efficacy not established
  • Children 4-17 years: 
  • Weighing 11 kg but less than 30 kg: 1 mg/kg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 1 mg/kg orally/IV twice daily, up to recommended 3-6 mg/kg orally/IV twice daily (6-12 mg/kg/day)
  • Weighing 30 kg but less than 50 kg: 1 mg/kg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 1 mg/kg orally/IV twice daily, up to recommended 2-4 mg/kg orally/IV twice daily (4-8 mg/kg/day)
  • Weighing 50kg or above: 50 mg orally/IV twice daily, then, based on response and tolerability, increase dose at weekly intervals by 50 mg orally/IV twice daily, up to recommended 150-200 mg orally/IV twice daily (300-400 mg/day) for monotherapy or 100-200 mg orally/IV twice daily (200-400 mg/day) for adjunctive therapy

Vimpat generic drug Lacosamide : drug Interactions

Patients with renal or hepatic impairment who are taking strong CYP3A4 and CYP2C9 inhibitors may have a significant increase in exposure to Lacosamide; dose reduction may be necessary.

• Lacosamide has severe interactions with no other drugs.
• Lacosamide has serious interactions with the following drugs:
  • adametapir
  • apalutamide
  • fexinidazole
  • idelalisib
  • ivosidenib
  • metoclopramide intranasal
  • tucatinib
  • voxelotor

This information does not contain all possible interactions or adverse effects. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Vimpat generic drug Lacosamide : Pregnancy and Lactation

• There are no adequate data on the developmental risks associated with Lacosamide use in pregnant women
• Lacosamide produced developmental toxicity (increased embryofetal and perinatal mortality, growth deficit) in rats following administration during pregnancy.
• Developmental neurotoxicity was observed in rats following administration during a period of postnatal development corresponding to the third trimester of human pregnancy.  
• There are no data on the presence of Lacosamide in human milk, the effects on the breastfed infant, or the effects on milk production
• Studies in lactating rats have shown excretion of Lacosamide and/or its metabolites in milk
• Developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Lacosamide and any potential adverse effects on the breastfed infant from Lacosamide or from the underlying maternal condition.
• Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Vimpat generic drug Lacosamide : Alcohol/Food Interactions

Using lacosamide together with Alcohol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination.

Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Vimpat generic drug Lacosamide : Mechanism of Action

Vimpat (lacosamide) is an antiepileptic. While it’s not exactly clear how the medication works to treat seizures, it’s thought to slow the activity of sodium channels in the brain. This helps to calm your brain activity to control seizures.

Vimpat generic drug Lacosamide : price

Vimpat generic drug Lacosamide: FAQ